TMC function in hair cell transduction
نویسندگان
چکیده
منابع مشابه
Stochastic Resonance in Hair Cell Mechanoelectrical Transduction
Hair cells are the mechanoelectrical transducers in the auditory system of many species, including humans. Experiments show that transduction in individual hair cells displays stochastic resonance, with optimum response at the natural noise level of living cells. We find that many of the observed features are captured by a simple version of a physiologically faithful model of the transduction m...
متن کاملWhat is the hair cell transduction channel?
In contrast to nearly all other sensory systems, the mechanically sensitive ion channel carrying the receptor current into hair cells of the inner ear has not been identified in molecular terms. A number of candidates from at least two different ion channel families have been considered: these include the epithelial sodium channel (ENaC) and acid-sensing ion channel (ASIC) members of the DEG/EN...
متن کاملMechanotransduction: The Elusive Hair Cell Transduction Channel Revealed?
A family of transmembrane proteins has been shown to modulate both the calcium permeability and single-channel conductance of the vertebrate hair-cell mechanosensor, implicating them directly in inner ear mechanosensation.
متن کاملFalsification of the ionic channel theory of hair cell transduction
The hair cell provides the transduction of mechanical vibrations in the balance and acoustic sense of all vertebrates that swim, walk, or fly. The current theory places hair cell transduction in a mechanically controlled ion channel. Although the theory of a mechanical input modulating the flow of ions through an ion pore has been a useful tool, it is falsified by experimental data in the liter...
متن کاملSignal transduction: Hair brains in bacterial chemotaxis
The conserved cytoplasmic domains of bacterial chemotaxis receptors are a fibrous arrangement of alpha-helical coiled coils that look a lot like hair. Such bundles of alpha-helical filaments mediate sensory-motor responses in all prokaryotic cells. How do they work? Very nearly perfectly is probably as good an answer as any.
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ژورنال
عنوان ژورنال: Hearing Research
سال: 2014
ISSN: 0378-5955
DOI: 10.1016/j.heares.2014.01.001